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Anti-Wrinkle Concentrate with Pentapeptide-18
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Product Description
1. MOA
Pentapeptide-18 is a synthetic biomimetic peptide, famously known under the trade name Leuphasyl®. Its mechanism is specifically designed to target and soften the appearance of dynamic expression lines through a neurocosmetic action.
Enkephalin-Mimetic Action:
The peptide's sequence is designed to mimic the natural function of enkephalins, which are endogenous neurotransmitters that act on opioid receptors to dampen neuronal signals.
It competitively inhibits the enzyme enkephalinase, which normally breaks down these calming neurotransmitters. This leads to an increased local concentration of enkephalins.
Reduction of Muscle Contraction Signals:
The elevated enkephalin levels help to down-regulate the release of acetylcholine, the primary neurotransmitter responsible for triggering muscle fiber contractions at the neuromuscular junction.
By moderating this signal, Pentapeptide-18 helps to reduce the intensity and frequency of micro-contractions in facial expression muscles, thereby preventing the formation and deepening of dynamic wrinkles (e.g., crow's feet, forehead lines, and frown lines).
2. In Vitro Efficacy Data
2. In Vitro Efficacy Data
In-vitro studies validate its targeted biological activity.
Enkephalinase Inhibition Assay: Demonstrates potent, dose-dependent inhibition of the enkephalinase enzyme, confirming its primary mechanism of action.
Acetylcholine Release Assay (Neuronal Cell Models): Shows a significant reduction in acetylcholine release upon treatment, validating its ability to moderate the key neurotransmitter responsible for muscle contraction.
Cell Viability Assay: Confirms the non-cytotoxic nature of the peptide, even at effective concentrations.
3. Clinical Results
Clinical studies with formulations containing 2-5% Pentapeptide-18 demonstrate visible reduction in the appearance of expression lines.
Study Design: 4-week, double-blind, placebo-controlled study with female volunteers aged 35-55, applying a cream with 4% Pentapeptide-18 twice daily.
Instrumental Results (Facial Imaging & 3D Analysis):
A significant reduction in the depth and volume of crow's feet and forehead lines was quantitatively measured after 28 days.
Visual & Photographic Assessment:
Clinical Grading: Expert graders noted a visible softening of expression lines and an overall more relaxed facial appearance at rest.
Subject Self-Assessment: A high percentage of participants reported that their skin looked smoother and that their expression lines were less pronounced, especially when making facial expressions.
Excellent Tolerance: The ingredient was very well-tolerated, with no reports of irritation or loss of sensation, making it suitable for continuous daily use.
Safety Profile
It is non-toxic, non-irritating, and does not interfere with essential biological functions or cause paralysis. It is considered a cosmetic ingredient, not a drug.
PH Compatibility
Effective in a wide pH range (4.5 - 7.0).
Formulation Compatibility
Synergistic with: Other anti-wrinkle peptides, Hyaluronic Acid (for surface plumping), and Matrix-building peptides (e.g., Palmitoyl Tripeptide-1) to address both dynamic and static wrinkles.
Compatible with: A broad range of emulsion systems, gels, and serums. Incorporation: Recommended to incorporate into the water phase at low to moderate temperatures (<40°C) with gentle stirring.
Compatible with: A broad range of emulsion systems, gels, and serums. Incorporation: Recommended to incorporate into the water phase at low to moderate temperatures (<40°C) with gentle stirring.
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Recommended Usage & Dosage
Recommended Usage Level: 3% - 6% in the final product.
Suggested Formulations:
Targeted Serums & Gels: For focused application on the forehead, around the eyes (crow's feet), and between the brows (frown lines).
Daily Anti-Aging Creams & Lotions: For all-over facial use to prevent and soften expression lines.
Eye Contour Creams: Specifically to address dynamic wrinkles in the delicate eye area.
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Targeted Neurocosmetic Action
Uniquely mimics the body's natural calming signals (enkephalins) to gently reduce the muscle contractions that cause expression lines.
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Non-Paralyzing & Safe
Offers a "Botox-like" effect through a reversible biochemical process, without causing numbness or interfering with natural expressions.
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Clinically Proven Efficacy
Significantly reduces the depth and appearance of dynamic wrinkles, such as crow's feet and forehead lines, as shown in clinical studies.
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Ideal for Daily Use
Its excellent safety profile makes it suitable for long-term, daily application to prevent and treat expression lines.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available